Department of Electrical Engineering, Yazd Branch, Islamic Azad University, Yazd, Iran
10.22034/apj.2025.730012
Abstract
Quantum genetic algorithm, which is a combination of quantum mechanics principles and evolutionary algorithms, has been proposed as a new method in the field of optimization. In recent years, numerous applications of these algorithms have been reported in solving complex biological problems such as gene and stem cell structure analysis, protein simulation, and molecular behavior prediction. This article aims to comprehensively review the performance of quantum genetic algorithm in biological problems, and reviews its theoretical foundations, functions, advantages, and challenges. Various studies have shown that quantum genetic algorithm, by utilizing quantum properties such as superposition and entanglement, has been able to improve the inefficient convergence problems of classical algorithms and provide more optimal solutions. Also, in the second part of the article, the architecture and technical mechanisms of quantum genetic algorithm are described and applied examples in biology are analyzed. Finally, the prospects of this technology in biological research are reflected by providing recommendations and perspectives for future developments.
Creevey FM, Jing M, Hollenberg LCL. Implementation of a quantum sequence alignment algorithm for quantum bioinformatics. arXiv preprint arXiv:2506.22775. 2025.
Nałęcz-Charkiewicz K, Mesjasz-Lech A, Nowak M. Quantum computing in bioinformatics: a systematic review. Brief Bioinform. 2024;25(5):bbae391.
Sarkar PR, Giannakis DA, Prousalis P. Quantum-inspired evolutionary algorithms in bioinformatics: Applications and challenges. Comput Biol Med. 2023;150:106126.
Layeb A, Meshoul S. A quantum genetic algorithm for optimization in biological sequence analysis. Int J Comput Biol Drug Des. 2006;1(4):345-357.
Mongia S, Gupta M, Shukla S. Quantum annealing for protein folding problem: A systematic approach. J Comput Chem. 2023;44(8):1012-1023.
Khan S, Ahmad S, Wong KF. Quantum Fourier transform techniques in molecular matching and screening: A review. IEEE Trans Comput Biol Bioinform. 2023;20(1):80-88.
Kösoglu-Kind Z, Nair RA, Memon S. A biological sequence comparison algorithm using quantum computing principles. Sci Rep. 2023;13:10456.
Hilali-Jaghdam I, Ferraro M, Vosoughi N. Quantum and classical genetic algorithms for multilevel medical image segmentation. Pattern Recognit. 2020;107:107481.
Sun J, Zhang J, Ouyang X. Quantum ant colony optimization algorithm for protein-protein interaction prediction. Evol Comput. 2012;20(2):303-320.
Creevey FM, Jing M, Hollenberg LCL. Implementation of a quantum sequence alignment algorithm for quantum bioinformatics. arXiv preprint arXiv:2506.22775. 2025.
Nałęcz-Charkiewicz K, Mesjasz-Lech A, Nowak M. Quantum computing in bioinformatics: a systematic review. Brief Bioinform. 2024;25(5):bbae391.
Sarkar PR, Giannakis DA, Prousalis P. Quantum-inspired evolutionary algorithms in bioinformatics: Applications and challenges. Comput Biol Med. 2023;150:106126.
Layeb A, Meshoul S. A quantum genetic algorithm for optimization in biological sequence analysis. Int J Comput Biol Drug Des. 2006;1(4):345-357.
Mongia S, Gupta M, Shukla S. Quantum annealing for protein folding problem: A systematic approach. J Comput Chem. 2023;44(8):1012-1023.
Khan S, Ahmad S, Wong KF. Quantum Fourier transform techniques in molecular matching and screening: A review. IEEE Trans Comput Biol Bioinform. 2023;20(1):80-88.
Kösoglu-Kind Z, Nair RA, Memon S. A biological sequence comparison algorithm using quantum computing principles. Sci Rep. 2023;13:10456.
Hilali-Jaghdam I, Ferraro M, Vosoughi N. Quantum and classical genetic algorithms for multilevel medical image segmentation. Pattern Recognit. 2020;107:107481.
Santos R, Bennett K, Lee E. Quantum genetic algorithm for protein structure prediction. Sci Rep. 2022;12:1548.
Dutra L, Pereira TC, Moura RDS. Quantum-inspired genetic algorithm for gene regulatory network inference from time-series data. Int J Genomics. 2023;2023:5698723.
Layeb A. A quantum genetic algorithm for extraction of optimal features for cancer classification. J Theor Biol. 2023;561:111342.
Gálvez MA, Calce FJ, Jiménez LO. Quantum genetic algorithm for DNA sequence analysis and feature selection. IEEE Access. 2020;8:204027-204040.
Mahdavi,E. (2025). Investigating the Quantum Genetic Algorithms in the Field of Biological Problems. Arman Process Journal (APJ), 6(2), 59-66. doi: 10.22034/apj.2025.730012
MLA
Mahdavi,E. . "Investigating the Quantum Genetic Algorithms in the Field of Biological Problems", Arman Process Journal (APJ), 6, 2, 2025, 59-66. doi: 10.22034/apj.2025.730012
HARVARD
Mahdavi E. (2025). 'Investigating the Quantum Genetic Algorithms in the Field of Biological Problems', Arman Process Journal (APJ), 6(2), pp. 59-66. doi: 10.22034/apj.2025.730012
CHICAGO
E. Mahdavi, "Investigating the Quantum Genetic Algorithms in the Field of Biological Problems," Arman Process Journal (APJ), 6 2 (2025): 59-66, doi: 10.22034/apj.2025.730012
VANCOUVER
Mahdavi E. Investigating the Quantum Genetic Algorithms in the Field of Biological Problems. APJ, 2025; 6(2): 59-66. doi: 10.22034/apj.2025.730012