A Review of Digital Twins’ Applications and Challenges in Healthcare and Medicine
Volume 6, Issue 4, Spring 2026, Pages 25-49
https://doi.org/10.22034/apj.2026.2077879.1059
Mohammad Hossein Roozbahani
Abstract The rapid growth of big data, coupled with advancements in data science and artificial intelligence, has significantly accelerated the potential for developing digital twins. A digital twin is a continuously updated virtual copy that enables the analysis, simulation, and prediction of a real-world object or process. Recently, applications of digital twins have seen substantial expansion across both academic communities and diverse governmental and military industries, and the healthcare sector is no exception. The concept of the digital twin for health promises a transformation in medical systems, encompassing service management and delivery, disease treatment and prevention, health maintenance, and ultimately, the enhancement of human life. By harnessing the ability to aggregate and analyze vast datasets from multiple sources, digital twins can facilitate personalized treatment pathways tailored to individual patient characteristics, medical history, and physiological data. This enables predictive analytics, preventative interventions, and the early identification of health risks and diseases through machine learning algorithms. Furthermore, digital twins can optimize clinical operations by analyzing treatment processes and resource allocation, leading to simplified and expedited treatment protocols. This review outlines the current applications of digital twins within the healthcare sector, delineates their core components in medicine, and examines the present landscape of open research opportunities. We demonstrate how the integration of diverse enabling technologies and tools—such as artificial intelligence, large language models, and mechanistic modeling—paves the way for overcoming limitations and fostering broader clinical adoption and implementation of digital twins. This review also aims to assist data scientists, clinicians, and policymakers in developing future medical digital twins and bridging the gap between this emerging paradigm's theoretical promise and practical realization.

